Iain J McEwan Selected Research

Androgens

9/2016	Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer.
5/2016	Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.
1/2016	EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor.
10/2014	Negative regulation of the androgen receptor gene through a primate-specific androgen response element present in the 5' UTR.
1/2012	The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity.
12/2005	Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions.

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Iain J McEwan Research Topics

Disease

21	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 12/2005
5	Neoplasms (Cancer) 01/2021 - 12/2005
2	Muscular Atrophy (Muscle Atrophy) 09/2015 - 11/2008
1	Bites and Stings (Sting) 09/2016
1	Prostatic Intraepithelial Neoplasia 05/2016
1	Disease Progression 01/2016
1	Androgen-Insensitivity Syndrome (Testicular Feminization) 01/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2008
1	Inflammation (Inflammations) 11/2005

Drug/Important Bio-Agent (IBA)

22	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 12/2005
6	AndrogensIBA 09/2016 - 12/2005
5	LigandsIBA 01/2022 - 12/2005
5	Pharmaceutical PreparationsIBA 01/2021 - 01/2012
4	Hormones (Hormone)IBA 01/2016 - 11/2005
3	enzalutamideIBA 11/2019 - 09/2016
3	Transcription Factors (Transcription Factor)IBA 01/2018 - 11/2008
3	Proteins (Proteins, Gene)FDA Link 05/2016 - 11/2008
2	Androgen Antagonists (Antiandrogens)IBA 01/2022 - 05/2012
1	Biological ProductsIBA 01/2019
1	PDZ-binding kinaseIBA 01/2019
1	Protein Isoforms (Isoforms)IBA 11/2017
1	Choline KinaseIBA 05/2016
1	Molecular Chaperones (Chaperone, Molecular)IBA 05/2016
1	Phosphotransferases (Kinase)IBA 05/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016
1	EPI 001IBA 01/2016
1	SolutionsIBA 01/2016
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2016
1	polyglutamineIBA 09/2015
1	abirateroneIBA 05/2012
1	Docetaxel (Taxotere)FDA Link 05/2012
1	GlucocorticoidsIBA 05/2012
1	Glutamine (L-Glutamine)FDA Link 11/2008
1	Amino Acids FDA Link 11/2008
1	SaltsIBA 11/2005
1	SteroidsIBA 11/2005

Therapy/Procedure

8	Therapeutics 01/2022 - 12/2005
8	Castration 11/2019 - 06/2010